I don’t consider oral estradiol to be bioidentical because...Swallow estradiol (E2), and it doesn’t stay estradiol. It takes a first pass through the liver—where most of it is transformed into estrone (E1).Estrone isn’t the same estrogen; it acts primarily on the alpha receptor. Now yes, it can convert back into estradiol. But that process is unreliable, and inflammation makes it even weaker. So what reaches your bloodstream isn’t estradiol, the hormone your ovaries once made—it’s mostly estrone
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I don’t consider oral estradiol to be bioidentical because...Swallow estradiol (E2), and it doesn’t stay estradiol. It takes a first pass through the liver—where most
Felice Gersh MD. Felice Gersh MD · Original audio. I don’t consider oral estradiol to be bioidentical because...Swallow estradiol (E2), and it doesn’t stay estradiol. It takes a first pass through the liver—where most of it is transformed into estrone (E1).Estrone isn’t the same estrogen; it acts primarily on the alpha receptor. Now ...
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