Semaglutide - ALZFORUM
Semaglutide is a synthetic, long-acting analog of glucagon-like peptide-1, used to treat diabetes. Ozempic TM is a once-per-week injection formulation, while Rybelsus TM is is a daily pill.
Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its ...
Lee TS, Park EJ, Choi M, Oh HS, An Y, Kim T, Kim TH, Shin BS, Shin S. Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain …
Semaglutide ameliorates cognition and glucose metabolism
Dec 1, 2023 · Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway. …
The Discovery and Development of Liraglutide and Semaglutide
Knudsen LB, Lau J. The Discovery and Development of Liraglutide and Semaglutide. Front Endocrinol (Lausanne). 2019;10:155. Epub 2019 Apr 12 PubMed.
New NLRP3 Inhibitor Acts In Brain to Melt Obesity | ALZFORUM
Oct 23, 2025 · NLRP3 inhibitor must pass into brain to effect weight loss in obese mice. The inhibitor calms microgliosis in the hypothalamus, raising hopes for such effects in other brain …
Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction ...
Rubin R. Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction, Alzheimer Disease, and Other Conditions?. JAMA. 2024 May 14;331 (18):1519-1521. PubMed.
ALZFORUM | NETWORKING FOR A CURE
Nov 25, 2025 · A large proteogenomic study identified 49 pQTLs, in either CSF or plasma, linked to cerebral small vessel disease. Immune and ECM proteins predominated.
Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in …
Zhang L, Zhang L, Li L, Hölscher C. Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease. J Parkinsons Dis. 2019;9 …
Semaglutide ameliorates Alzheimer's disease and restores …
Zhang Y, Tang C, He Y, Zhang Y, Li Q, Zhang T, Zhao B, Tong A, Zhong Q, Zhong Z. Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice and …
ALZFORUM | NETWORKING FOR A CURE
Chang YF, Zhang D, Hu WM, Liu DX, Li L. Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis. J Clin Neurosci. 2020 …