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Transfer RNA-derived small RNAs transform the landscape of liquid biopsy
A new review highlights the transformative potential of transfer RNA-derived small RNAs (tsRNAs) in the field of liquid ...
Engineered enzyme enables detailed mapping of tRNA changes in tumor cells
An engineered enzyme is at the center of a new method to visualize molecular details in human cells, and how these molecules ...
eLife6mon
Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA
Our data suggest a mechanism by which mycobacterial ribosomes can discriminate mischarged tRNAs and that 16S rRNA differential methylation by ... could better discriminate against misacylated-tRNA.
News Medical2y
Types of RNA: mRNA, rRNA and tRNA
Ribosomes are composed of a large subunit called the 50S and a small subunit called the 30S, each of which is made up of its own specific rRNA molecules ... all species. tRNA is the smallest ...
eLife2y
The layered costs and benefits of translational redundancy
tRNA modifying enzymes, and rRNA molecules – many of which are redundant in terms of gene copy number or function. It has been hypothesized that the redundancy evolves under selection, driven by its ...
Frontiers3y
Genetic and Functional Analyses of Archaeal ATP-Dependent RNA Ligase in C/D Box sRNA Circularization and Ribosomal RNA Processing
A comparative analysis of circular RNA reveals that the Rnl-knockout strain represses circularization of C/D box sRNAs without affecting the circularization of tRNA and rRNA processing intermediates.
The EMBO Journal4y
A stress‐induced tyrosine‐tRNA depletion response mediates codon‐based translational repression and growth suppression
tRNA Tyr GUA depletion impairs translation of growth genes that ... Barcoded pre‐adenylated linkers were ligated using T4 RNA ligase 2 truncated K227Q (NEB) and rRNA was depleted using the Ribo‐Zero ...
The EMBO Journal4y
The tRNA‐like small noncoding RNA mascRNA promotes global protein translation
tRNA‐like noncoding RNA mascRNA increases the cytosolic protein ... Gel shift assay of biotin‐labeled mascRNA and 5S rRNA with the cytosol (Cyto) and the postnuclear membrane lysate (Mem). B. Northern ...
Frontiers4y
Possible Roles for Basal Levels of (p)ppGpp: Growth Efficiency Vs. Surviving Stress
Recent discoveries that abrupt amino acid starvation of Escherichia coli, accompanied by very high levels of ppGpp, occasion surprising instabilities of transfer RNA (tRNA), ribosomal RNA (rRNA), and ...
News Medical7y
rRNA, tRNA, and mRNA Modifications
Nascent pre-rRNA molecules are immediately bound by proteins ... and base modifications as indicated below: The tRNA processing takes place in the nucleoplasm and are transmitted to the cytoplasm ...
istockphoto7y
Trna stock illustrations
The mRNA decoding ribosomes. steps diagram with cycle explanation Types of RNA. tRNA, mRNA and rRNA Types of RNA. tRNA for transfer, that helps to decode information present in mRNA, rRNA in ribosome, ...