In the phase 3 EMBARK trial, enzalutamide plus leuprolide and enzalutamide monotherapy were associated with longer metastasis ...

Additional efforts are needed to improve quality of life and mitigate suffering in people with sickle cell disease. The field ...

Patients with previously untreated, locally advanced, unresectable or metastatic triple-negative breast cancer who are not ...

When a pediatrician caring for patients with a rare genetic disease discovers incidentally that he carries his own rare high-risk mutation, he must learn from a patient’s parents how to shift his ...

The concept of adjuvant therapy for cancer was developed at a time when systemic cancer treatment was limited to cytotoxic chemotherapy that could only be administered intermittently but rarely ...

A baby boy was transferred to a tertiary care hospital 5 days after birth. He had an intact manubrium but no corpus of the sternum, which had resulted in complete displacement of the heart outside ...

A 43-year-old woman with bipolar disorder and advanced HIV infection was admitted to this hospital because of depressed mood, suicidal ideation, cough, and a temperature of 39.5°C. A diagnosis was ...

Digital tobacco-cessation treatments hold great promise. But dedicated efforts will be required to promote access to and ...

Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; ...

Idiopathic intracranial hypertension, also called pseudotumor cerebri, refers to elevated cerebrospinal fluid (CSF) pressure that develops most often in women of reproductive age with obesity, causing ...

A 22-year-old woman presented with a 3-month history of bumps on the right ventral surface of her tongue. On physical examination, the bumps were observed to be pink papillomatous lesions measuring 3 ...