Background Abnormal lung volumes that reflect air trapping are common in COPD. However, their significance in smokers with preserved spirometry (normal FEV1 to FVC ratio) is unclear. Methods Using the ...

Recommendations Long-term macrolide treatment could be offered to reduce exacerbations in those with high exacerbation rates (ie, 3 or more per year). (Strong) The dosing regimens with the greatest ...

Introduction COPD is a heterogeneous disorder with varied phenotypes. We aimed to determine the prevalence of asthma history, peripheral eosinophilia and elevated FeNO levels along with the diagnostic ...

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COPD is a progressive disease where airway inflammation plays an important part. Previously, there were large expectations that regular anti-inflammatory treatment with inhaled corticosteroids (ICS) ...

Background Infections with some bacteria, including Streptococcus pneumoniae , have been associated with a reduced incidence of asthma. Components of S pneumoniae may have the potential to modulate ...

Background Antimicrobial resistance (AMR) is a growing global health crisis and is particularly relevant to people living ...

Background: In some patients chronic asthma results in irreversible airflow obstruction. High resolution computed tomography (HRCT) has been advocated for assessing the structural changes in the ...

Background: Considerable research has been conducted into the nature of airway inflammation in chronic obstructive pulmonary disease (COPD) but the relationship between proximal airways inflammation ...

To determine whether asthma alone can cause irreversible airflow obstruction 42 men and 47 women with chronic asthma (mean duration 22 (SD 13) years) without evidence of other disease likely to cause ...

Background Up to 50% of patients suffering acute pulmonary embolism (PE) demonstrate impaired pulmonary vascular recovery at follow up despite optimal anticoagulation, impacting negatively on ...

Introduction Paediatric sleep diagnostics uses complex multi-channel tests in specialised centres, limiting access, delaying diagnosis and management. Children with neurodevelopmental disorders, at ...