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Don't Ignore These Early Signs of a Progressive Liver Condition
A progressive liver condition affects thousands of Americans, but early symptoms are often dismissed as everyday ailments. Learn the critical warning signs of Primary biliary cholangitis (PBC) and ...
Gastroenterology Advisor1d
Primary Biliary Cholangitis Rates Increasing in Western Pacific
The global prevalence of primary biliary cholangitis (PBC) has increased, particularly in the Western Pacific region of the world, according to study results published in Clinical Gastroenterology and ...
EMA Accepts GSK's Filing for Linerixibat in Rare Disease-Related Itch
GSK's marketing application for linerixibat, targeting cholestatic pruritus in PBC patients, gains EMA acceptance based on phase III success.
Pharmabiz2d
EMA accepts GSK’s MAA for linerixibat for cholestatic pruritus in patients with primary biliary cholangitis
EMA accepts GSK’s MAA for linerixibat for cholestatic pruritus in patients with primary biliary cholangitis: London, UK Tuesday, June 24, 2025, 09:00 Hrs [IST] GSK plc announced ...
gut.bmj2d
British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis | Gut
Similar to clinical outcomes in primary biliary cholangitis (PBC), recent data from retrospective studies support the use of falling ALP (normalisation or <1.5 x upper limit of normal (ULN)) as a ...
pharmaphorum3d
EU kicks off review of GSK's linerixibat in PBC
The EMA has started a review of GSK's treatment candidate for primary biliary cholangitis (PBC), linerixibat, offering hope ...
EMA accepts marketing authorisation application for GSK's linerixibat
GSK said on Monday that the European Medicines Agency has accepted its marketing authorisation application for linerixibat, an investigational treatment for cholestatic pruritus in patients with ...
gut.bmj4d
Case–control studies of risk factors for primary biliary cirrhosis in two United Kingdom populations - Gut
Objective The aetiology of primary biliary cirrhosis (PBC) is largely unknown. Previous studies have indicated that both environmental and genetic risk factors may be important. Design We undertook a ...
Lisa thought her itch was just an allergy. In fact it was a common liver problem that mostly strikes women, often goes undetected for years and causes catastrophic da…
Lisa Woodcock's initial instinct when she first developed severe itching all over her body was to blame an allergic reaction ...
Dermatology Advisor9d
Linerixibat Under Review for Cholestatic Pruritus in PBC Patients
The FDA has accepted for review the NDA for linerixibat for the treatment of cholestatic pruritus in patients with primary biliary cholangitis.
Nature9d
Unraveling the Pathogenesis and Etiology of Biliary Atresia | Pediatric Research - Nature
Biliary atresia (BA) ... Chapman RW 1991 Role of immune factors in the pathogenesis of primary sclerosing cholangitis. Semin Liver Dis 11: 1–4. Article CAS PubMed Google Scholar ...
Nature12d
Renaming primary biliary cirrhosis—clarity or confusion?
What is in a name; and why does the nomenclature of one disease, primary biliary cirrhosis, cause such contention that a proposed name change by those deeply committed to the advancement of its ...