The Indianapolis Colts take the AFC South lead by extending the Arizona Cardinals' losing streak: Stats, scores.

Jonathan Taylor’s one-yard touchdown run gave Indianapolis the lead in the fourth quarter, and the Colts withstood a final drive into the red zone by the visiting Arizona Cardinals with less than a minute left to pull out a 31-27 victory on Sunday and improve to 5-1.

It all came to an end on the Indianapolis 9-yard line. On fourth-and-7 with under a minute remaining, Jacoby Brissett fired beyond the reach of Trey McBride, who protested for a penalty flag that never arrived. Cornerback Chris Lammons, the nearest defender, appeared to wrap both arms around McBride at the top of his route.

Jones and running back Jonathan Taylor has led this offense to new heights. Heading into Week 7, Indianapolis leads the NFL in team points with 194, ahead of the Detroit Lions (191) and Dallas Cowboys (178).

Since returning to the lineup, the Cardinals have scored on nine of the 13 possessions Will Hernandez has played.

The Indianapolis Colts played the Arizona Cardinals in NFL Week 6 action. Here's the breakdown: Stats, scoring plays, team stats.

Jacoby Brissett threw for 320 yards and helped the Cardinals score 27 points in Week 6. In the process, he revealed Kyler Murray's limitations.

The Arizona Cardinals suffered their fourth consecutive loss on Sunday, a 31-27 defeat on the road to the Indianapolis Colts. For the sixth consecutive week, the defense, especially late in the game, came into question. Their defense showed up in an interesting way in Week 6 in Nest Gen Stats.

Indianapolis Colts wide receiver Josh Downs (1) celebrates after scoring a touchdown against the Arizona Cardinals during a game on Sunday, Oct. 12, 2025, at Lucas Oil Stadium in Indianapolis. The Colts defeated the Cardinals 31-27. / Christine Tannous/IndyStar / USA TODAY NETWORK via Imagn Images