Primary biliary cholangitis, or PBC, can cause damage to the bile ducts and liver. There is currently no cure for the disease. Learn more here.

Pain and swelling in your abdomen; Joint, bone, or muscle pain; ... When your bile ducts are injured, which is what happens with PBC, those substances hang around in your liver, ...

Five to 10 percent of people with PBC don’t have AMAs in their blood. ‌If you test positive for AMAs, the test results will also tell you what level, or titer, you have.

Medically reviewed by Jay N. Yepuri, MD Primary biliary cholangitis (PBC), also known as primary biliary cirrhosis, is a chronic and progressive disease that damages and can eventually destroy the ...

PBC is diagnosed with a blood test that measures liver enzymes. One common test analyzes the patient’s alkaline phosphatase (ALP), an enzyme that helps detect liver or bone disease.

Lowrey writes about living with PBC in the Atlantic article, "Why People Itch and How to Stop It."She says a big part of her struggle is coming to terms with the fact that she may never feel fully ...

Linerixibat induced a dose-dependent reduction in itch among patients with primary biliary cholangitis-associated pruritus, according to results published in Clinical Gastroenterology and Hepatology.

With the FDA approval of Livdelzi, people with PBC have good reason to be excited about future treatment options available to them. Livdelzi is a drug now proven to be effective at improving both ...

Seladelpar for PBC was granted breakthrough designation in October 2023. The study was funded by CymaBay Therapeutics. Disclosures for authors and editorialist are available at NEJM.org.

The most common adverse reactions with Livdelzi were headache, abdominal pain, nausea, abdominal distension, and dizziness. The company noted that the FDA granted accelerated approval for Livdelzi ...

Ipsen estimates that PBC affects 100,000 people in the U.S. Standard treatment is ursodeoxycholic acid (UDCA), an old drug for dissolving gallstones that has an additional approval for treating PBC.