Wojciech Jurczak, MD, PhD, discusses advancements in B-cell lymphoma therapy, focusing on immunotherapy, molecular-targeted agents, and more.

In conclusion, our study provides compelling evidence that JT can mitigate renal fibrosis and improve renal function in a CKD model through mechanisms involving the SIRT3/P53 signaling pathway and the ...

The DREAM complex is a transcriptional repressor whose expression is regulated indirectly via p53-mediated induction of the CDK inhibitor p21. Here, p53 is found to directly regulate DREAM complex ...

Oscillatory p53 expression occurs in individual cells responding to DNA breaks. While the majority of cells exhibit the same qualitative response, quantitative features of the oscillations (e.g., ...

Figure 7. Schematic representation of how melatonin suppresses ferroptosis and ameliorates AMD via the PI3K-AKT-driven MDM2/P53/SLC7A11 pathway. The stimulation of MDM2 results in the inhibition of ...

MANILA – The Philippine Economic Zone Authority (Peza) has approved P52.93 billion worth of investment pledges in the first two months of the year. PEZA reported Tuesday that its investment ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.