The study also revealed distinct signaling profiles: ζ111 CAR T cells showed stronger phosphorylation and activation of ITAM-proximal signaling molecules (ZAP-70, LAT, PLCγ), resulting in higher ...

Trump Calls Signal Leak Fallout a ‘Witch Hunt’ Speaking to reporters from the Oval Office, the president focused on the successful U.S. airstrikes in Yemen more than the discussion of military ...

Receptor tyrosine kinases (RTKs) are major signaling hubs in metazoans, playing crucial roles in cell proliferation, migration, and differentiation. However, few tools are available to measure the ...

Although we could not exclude the indirect binding of PTEN to FcRγ, PTEN has been identified as a negative regulator of FcR signaling, an ITAM-based signaling event. For examples, PTEN abrogates ...

We next examined signaling downstream of the SFKs in the presence and absence of receptor clustering. To investigate signaling in response to receptor clustering, we treated macrophages with zymosan, ...

Platelet ITAM signaling strongly depends on the Ca 2+ /CalDAG-GEFI/Rap1 pathway as deficiency in CalDAG-GEFI protects mice from collagen- and immune complex–induced thrombosis. 57,61 It is important ...

Immunoreceptor tyrosine-based activation motifs (ITAMs) and ITAM-like adaptors are some of the most widely used conserved signaling modules in leukocytes 1.The same ITAM is found in the ...

The activation state of many blood and vascular cells is tightly controlled by a delicate balance between receptors that contain immunoreceptor tyrosine-based activation motifs (ITAMs) and those that ...

The researchers found that activation of the ITAM receptor set off a pathway known as DAP12-Syk-Pyk2-p38-MSK that was dependent on calcium signaling and discouraged pro-inflammatory cytokine ...

An improved Taylor approximation method (ITAM) algorithm is proposed, and a comparison of the new algorithm with the conventional Taylor approximation method (TAM) algorithm is presented in this paper ...

ITAM-associated receptors have been shown to regulate signaling by the TNFR family members receptor activator of NF-κB (RANK) and BLyS receptor 3 (BR3, also called BAFFR).