Objective To evaluate the efficacy and safety of an oral selective tyrosine kinase 2 (TYK2) inhibitor, deucravacitinib, in patients with active psoriatic arthritis (PsA). Methods In this double-blind, ...

As of February 28, 2025, 99 patients were enrolled (Phase 1a, n=8; Phase 1b, n=6, Phase 2, n=30, 25, and 30 in Cohorts A, B, and C, respectively). The baseline characteristics are summarized below: ...

The Montreal Protocol The Montreal Protocol on Substances that Deplete the Ozone Layer is the landmark multilateral environmental agreement that regulates the production and consumption of nearly 100 ...

MAIA has announced the trial design for an expansion of its THIO-101 pivotal Phase 2 trial in NSCLC to assess overall response rates (ORR) in advanced NSCLC patients receiving third line ...

Claudin-18 isoform 2 (CLDN18.2) has emerged as a promising therapeutic target in gastric or gastro-oesophageal junction cancer. Satricabtagene autoleucel (satri-cel; also known as CT041), an ...

We applied the IU conversion method to validate the consistency of immunogenicity between our phase 1 and phase 2 trials from different laboratories. Using the WHO IU, the GMT on day 57 in our phase 1 ...

2:02 Phase 2 of Valley Line West LRT road closures begin. The City of Edmonton is moving into the next phase of its accelerated roadwork this summer to make room for the Valley Line West LRT.

CMRL will upgrade Chennai’s public transport network by introducing its first driverless metro train by February 2027. As part of Chennai Metro Rail Limited’s (CMRL) Phase-2 expansion, this ...

TXDOT says this closure is partly due to phase 2 of the $53 million project to extend the I-69 Brazos River Bridge and the feeder lanes north by 1,000 feet.

The Cabinet also cleared the decks for the Hyderabad Metro Phase 2B project, to be executed jointly by the State and Central governments at an estimated cost of ₹19,579 crore. The project spans ...

Corcept Therapeutics has tried to cast its recent phase 2 amyotrophic lateral sclerosis (ALS) failure in a more flattering light by pointing to promising survival data.. The biopharma revealed in ...

Newt Gingrich: This is the 'soap opera' phase of American politics. Former House Speaker Newt Gingrich weighs in on President Donald Trump and Elon Musk's feud over the 'big, beautiful bill' on ...