Viral proteases, the key enzymes that regulate viral replication and assembly, are promising targets for antiviral drug discovery. Herpesvirus proteases are enzymes with no crystallographically ...

Background: Glutamine is required for the growth and survival of multiple tumor types. CB-839 is a highly selective, reversible, allosteric inhibitor of glutaminase, a choke point in the utilization ...

Machine learning helps improve accuracy and efficiency of small-molecule calculations Microsoft researchers used deep learning to create new DFT model by Sam Lemonick, special to C&EN June 20, 2025 ...

Scientists have identified that the molecule cardiotrophin-like cytokine factor 1 (CLCF1) surges through the bloodstream during workouts, particularly resistance training. This protein appears to ...

Several distinct spectral lines aligned precisely with those of the aromatic molecule, confirming its presence with strong statistical significance. The seven ring polycyclic aromatic hydrocarbon (PAH ...

Biohybrid molecule uses light-driven electrons to efficiently produce hydrogen by Ruhr University Bochum edited by Lisa Lock, reviewed by Robert Egan Editors' notes ...

Study identifies molecule in stingless bee propolis that can kill dengue mosquito larvae by André Julião, FAPESP edited by Sadie Harley, reviewed by Robert Egan Editors' notes ...

Abstract: Existing drug discovery pipelines take 5–10 years and cost billions of dollars. Computational approaches aim to sample from regions of the whole molecular and solid-state compounds called ...

A new molecule developed by UB researchers acts like a local, long-lasting anesthetic, providing robust pain relief for up to three weeks, according to the results of preclinical studies reported ...

Designing new molecules is essential for drug discovery and material science. Recently, deep generative models that aim to model molecule distribution have made promising progress in narrowing down ...

Large-scale nanoarrays of single biomolecules enable high-throughput assays while unmasking the underlying heterogeneity within ensemble populations. Until recently, creating such grids which combine ...

And the results of the study, by providing proof of concept for a molecule that can reverse cognitive decline without affecting beta-amyloid plaques, support the hypothesis that these, although ...