Many of the affected genes have roles in key processes such as cell adhesion and migration, which are known to respond to mechanical forces. The researchers found that sound expanded the size of the ...

Finally, further ECM components need to be studied to understand the whole range of cell–ECM–PMS interactions, for example by using micropatterned ECM substrates on PNIPAm including also collagen 4, ...

ECM degradability, defined as the rate at which cells enzymatically digest the matrix, significantly influences cell behavior. Studies suggest that degradation of ECM is a prerequisite for successful ...

Thus, our results demonstrate opposing roles for cell-cell and cell-ECM adhesion during epithelial folding. While cadherin-mediated adhesion, linked to actomyosin network, regulates apical folding, a ...

"The study highlights the close interaction between lysosomal exocytosis and focal adhesions, underscoring their critical ...

Cadherin 17 (CDH17), involved in cell-cell adhesion, is overexpressed in gastrointestinal cancers, including CRC. 60,61 The study by Feng et al demonstrated that CDH17-targeted CAR-T cells could ...

Estrogen-related receptor gamma (ERRγ) was overexpressed in metastatic SCLC tumors, showing a positive correlation with disease progression. We uncovered a role for ERRγ in the regulation of ...

Cell-matrix adhesion is formed through the utilization of cell adhesion molecules that bind to the cell surface of the ECM. Anchor proteins are also used to mediate linkages, or are employed in ...

The adhesive's remarkable adhesion strength of (18.9 ± 0.9) MPa on steel substrates and adhesion energy of (40.0 ± 5.3) J·m −2 on pigskin surpassed many reported adhesives.

A critical step in cell migration is the interaction between the cell and the extracellular matrix (ECM). The cell connects to the ECM via the actin cytoskeleton. This connection is mediated by ...