In the phase 3 EMBARK trial, enzalutamide plus leuprolide and enzalutamide monotherapy were associated with longer metastasis ...

The concept of adjuvant therapy for cancer was developed at a time when systemic cancer treatment was limited to cytotoxic chemotherapy that could only be administered intermittently but rarely ...

Additional efforts are needed to improve quality of life and mitigate suffering in people with sickle cell disease. The field ...

When a pediatrician caring for patients with a rare genetic disease discovers incidentally that he carries his own rare high-risk mutation, he must learn from a patient’s parents how to shift his ...

A baby boy was transferred to a tertiary care hospital 5 days after birth. He had an intact manubrium but no corpus of the sternum, which had resulted in complete displacement of the heart outside ...

Patients with previously untreated, locally advanced, unresectable or metastatic triple-negative breast cancer who are not ...

A 43-year-old woman with bipolar disorder and advanced HIV infection was admitted to this hospital because of depressed mood, suicidal ideation, cough, and a temperature of 39.5°C. A diagnosis was ...

Teclistamab, a T-cell engager targeting B-cell maturation antigen, showed promise as a rescue therapy in 10 patients with refractory autoimmune diseases and led to clinical and serologic improvemen ...

Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; ...

Much of the food consumed in the United States is ultraprocessed. Evidence indicates that ultraprocessed food, as a class, has contributed to high rates of chronic diseases.

Idiopathic intracranial hypertension, also called pseudotumor cerebri, refers to elevated cerebrospinal fluid (CSF) pressure that develops most often in women of reproductive age with obesity, causing ...

To the Editor: The Case Record discussed by Kotton et al. (June 19 issue)1 addresses a case of deceased organ donor–transmitted strongyloidiasis,1 a rare but serious complication of transplantation ...