Computational models of the glucoregulatory system constitute a powerful tool for preclinical evaluation and mechanistic insight into therapeutics. However, in the case of diabetes, there is a dearth ...

The high clinical failure rate of small-molecule drugs is inarguably attributable to the lack of reliable predictions of chemical structure–efficacy–toxicity relationships that are applicable to ...

We herein disclose a mild and efficient cadmium-catalyzed domino reaction for accessing 1,6-enynes via a sequential A 3 -coupling/1,5-hydride transfer/hydrolysis/A 3 -coupling. This method ...

Protein–ligand binding affinity may be affected by protein mutations, especially point mutations occurring within the binding site, which may indirectly contribute to interindividual differences in ...

Low loose bulk density, a characteristic commonly observed in large accumulations of needle-like crystals, has caused numerous issues in both production processes and daily life. Antisolvent ...

We report an iridium-catalyzed asymmetric formal [3 + 2] cycloaddition between carboxylic acids and vinylcyclopropanes to access highly enantioenriched tetrahydrofurans. This reaction proceeds under ...

ConspectusPhotovoltaics (PVs) are currently the most economical and location-independent source of electricity generation, and their demand is growing rapidly as a sustainable renewable energy source.

Colloidal particles can co-assemble into multicomponent ordered superstructures, with their properties determined by the individual building blocks. Here, we demonstrate that covalent organic ...

Fruit spoilage has led to significant food waste and economic losses and poses risks to human health. Currently, widely used plastic bag preservation techniques exhibit limited effectiveness, often ...

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Prostate cancer is a common male malignancy. Although androgen deprivation therapy (ADT) is initially effective, it often leads to castration-resistant prostate cancer (CRPC) eventually.

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