eLife26m
No effect of additional education on long-term brain structure – a preregistered natural experiment in thousands of individuals
A regression discontinuity analysis finds essentially no effect of 1 additional year of secondary education on brain structure in adulthood. This is a valuable finding that adds to the literature on ...
eLife19h
Difficulty in artificial word learning impacts targeted memory reactivation and its underlying neural signatures
Targeted memory reactivation improved memory performance of easy-to-learn words, but had no effect of difficult-to-learn words, which suggests a critical role of word learning difficulty in sleep ...
eLife3d
Stochastic cell-intrinsic stem cell decisions control colony growth in planarians
The School of Neurobiology, Biochemistry & Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel ...
eLife3d
Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions
For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.
eLife3d
Distinct functions of three Wnt proteins control mirror-symmetric organogenesis in the C. elegans gonad
Organogenesis requires the proper production of diverse cell types and their positioning/migration. However, the coordination of these processes during development remains poorly understood. The gonad ...
eLife4d
RNase III in Salmonella Enteritidis enhances bacterial virulence by reducing host immune responses
This useful study examines the function of the rnc gene, which encodes the RNase III ribonuclease, as it relates to virulence of Salmonella Enteritidis. The authors demonstrate that the rnc gene is ...
eLife4d
Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria
This important study explores the interplay between gene dosage and gene mutations in the evolution of antibiotic resistance. The authors provide solid evidence to connect proteostasis with gene ...
eLife5d
HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest
This valuable study uses robust time-dependent microscopy assays to show that during HIV-1 infection, the viral accessory protein Vif causes cell cycle arrest during metaphase and not G2/M as ...
eLife6d
Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome
Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has ...
eLife6d
Notch Signaling: Antibodies get under the skin
By inhibiting receptor-ligand interactions in sebaceous glands, antibodies may be able to treat certain skin conditions.
eLife5d
Spatial transcriptomics of meningeal inflammation reveals inflammatory gene signatures in adjacent brain parenchyma
Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.
eLife6d
Image Correlation Spectroscopy is a Robust Tool to Quantify Cellular DNA Damage Response
This valuable paper shows image correlation spectroscopy (ICS) as a new tool to analyze the clustering of proteins involved in DNA damage response (DDR). The solid evidence presented demonstrates that ...