The San Francisco 49ers have lost back to back games and are losers in three of their last five, falling to 5-6 on the season. With their playoff chances dwindling by the week, there has been some ...

San Francisco 49ers defensive end Nick Bosa (hip/oblique) was pulled from his team's Week 11 loss to the Seattle Seahawks due ...

Buffalo Bills look to extend its six-game win streak as Josh Allen faces an unfamiliar foe in the San Francisco 49ers at ...

Former Bills linebacker Leonard Floyd had a message for Josh Allen and his other former Buffalo teammates ahead of Sunday ...

If the Bills do clinch the AFC East on Sunday, they'd be the earliest team to win a division since the New Orleans Saints won ...

Our top pick for the 49ers vs. Bills Week 13 NFL matchup is to bet on the 49ers +6.5 (+100). This betting advice is ...

The Buffalo Bills ' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

San Francisco 49ers edge rusher Leonard Floyd is excited to face his former Buffalo Bills and ex-teammate Josh Allen in Week ...

In this Thanksgiving special episode, Nate Tice and Charles McDonald dive into a packed Week 13 slate with plenty of playoff ...

Star receiver George Kittle and the San Francisco 49ers meet the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

Seahawks All Access takes you on the field and the sidelines with all the sights and sounds from the team's Week 12 win over ...