The Bills (10-2) ended up winning in a rout in a 35-10 final over the 49ers (5-7). That was just the start of it. On a ...

In Sunday's 35-10 win over the San Francisco 49ers, The Buffalo Bills used Alec Anderson as a third tackle on 17 plays, and ...

AP photographers captured some of the greatest moments from around the sports world last week, including action shots, ...

Donations have flooded in for the cancer survivor who was allegedly pushed down the stairs at Sunday's Bills game, with her ...

RB Christian McCaffrey suffers potentially season-ending knee injury in loss to Bills, adding to team's struggles.

There's even a chance Guerendo, who pulled his hamstring on the first day of training camp and missed the first two preseason ...

Christian McCaffrey may have suffered an isolated PCL tear against the Buffalo Bills, a rare injury that could end his season ...

Lost in all the snow and scoring in Buffalo’s 35-10 blowout of the visiting San Francisco 49ers was linebacker Matt Milano’s ...

Isaac Guerendo and Will Levis are among UPI senior sports writer Alex Butler's top fantasy football waiver wire priorities ...

Josh Allen’s memorable week began with singer and actress Hailey Steinfeld accepting his proposal for marriage and ended with ...

Now that we are 13 weeks into the season, let’s take a look around the NFL offenses and rank them from 32 to 1.

Guard Ben Bartch and defensive tackle Evan Anderson got their first-ever starts for the 49ers and both played well in snowy ...