High threshold clinical responses (Investigator’s Global Assessment Score 0 or 1, and Psoriasis Area and ... in adult patients with palmoplantar pustulosis (PPP). The primary endpoint of the ...

Other potential disease targets include palmoplantar pustulosis, generalised pustular psoriasis and pyoderma gangrenosum. Several further phase 2 trials are planned soon, the company said.

For example, skin-related disorders, such as palmoplantar pustulosis, psoriasis and acne conglobata, occur in up to 30% of pediatric and adolescent patients with CNO. [2] Radiography of bone ...

Improved targeting of the molecular drivers of psoriasis has paved the way for new oral therapies ... For example, a study of apremilast (Otezla) in palmoplantar pustulosis showed that up to 70% of ...

Phase IIIb studies are ongoing in palmo-plantar psoriasis, nail psoriasis and palmo-plantar pustulosis. Cosentyx is also in phase III development for psoriatic arthritis (PsA) and ankylosing ...

The condition most commonly occurs in infants and children. Palmoplantar pustulosis is a rare type of psoriasis that may cause painful blisters on the palms of your hands and soles of your feet.

and their safety profile was similar with previous safety findings from other psoriasis risankizumab trials. Palmoplantar pustulosis is typified by recurrent flare-ups and remissions and mostly ...

It is a subtype of pustular psoriasis. Palmoplantar co-occurs with nail psoriasis (also known as psoriatic onchodystrophy) in more than 50% of cases. This can cause the nail plate to thicken, lift, ...

Patients with generalized pustular psoriasis (GPP) experience frequent flares, and treatment alterations of off-label agents are frequently observed.

Generalized pustular psoriasis may be caused or triggered by various factors, including genetic mutations, infections, and certain medications. Generalized pustular psoriasis (GPP) is a severe ...

Stress, infections, and corticosteroid withdrawal are known triggers of generalized pustular psoriasis (GPP). However, doctors cannot attribute every GPP flare to a specific cause. Psoriasis is an ...