Metastatic cancer is an advanced stage where cancer cells spread beyond the original site. It’s harder to treat, often resisting chemotherapy and requiring more targeted, ongoing treatment approaches.

Jennifer Frederick didn't understand why she had a growing lump under her skin. A doctor returned a devastating diagnosis.

Early surgical consultation in a multidisciplinary approach should be encouraged for patients with metastatic melanoma to optimize outcomes,” the researchers wrote.

Wong PF, Wei W, Gupta S, et al. Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma. J Immunother Cancer. 2019;7 (1):194. doi:10.1186 ...

Blocking metastasis is critical since the five-year survival rate for people whose melanoma is detected and treated before it spreads is greater than 99% but drops to 35%, once the cancer has ...

In a large phase III trial of 676 advanced, inoperable melanoma patients published in 2010 in the New England Journal of Medicine, subjects previously treated unsuccessfully with other agents who ...

Conclusion Melanoma treatment is advancing rapidly, with significant progress in neoadjuvant and adjuvant therapies and the introduction of new options for metastatic disease.

More information: Leona A. Nease et al, Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis, Nature Cancer (2024). DOI: 10.1038/s43018-024-00844-8 ...