ITAM-associated receptors have been shown to regulate signaling by the TNFR family members receptor activator of NF-κB (RANK) and BLyS receptor 3 (BR3, also called BAFFR).

Immunoreceptor tyrosine-based activation motifs (ITAMs) and ITAM-like adaptors are some of the most widely used conserved signaling modules in leukocytes 1.The same ITAM is found in the ...

The researchers found that activation of the ITAM receptor set off a pathway known as DAP12-Syk-Pyk2-p38-MSK that was dependent on calcium signaling and discouraged pro-inflammatory cytokine ...

Using the mouse population, the RIKEN team has provided genetic evidence that all myeloid receptors that initiate signals through an ITAM-containing protein need CARD9 and two other adaptor proteins, ...

Syk recognizes doubly phosphorylated regions of the receptor called ITAM to initiate membrane signaling in an adaptive immune response. Syk additionally plays a role in signaling away from the ...

Previous studies had shown that the ITAM pathway signaling components directly suppressed so-called Toll-like receptor signaling molecules involved in inflammation, but there was a hint that an ...