A hit shows that there is “at least in principle, a molecule out there in the universe that does what I want it to,” he says. “At least it de-risks the concept.” In addition to considering ...

Could the secret to glowing, youthful skin be hiding in your brain? Dr. Nicholas Perricone, a leading dermatologist and nutritionist, has spent decades warning that chronic inflammation is one ...

A different, more optimized version of the molecule, called PX578, has been advanced to the clinic. That compound recently entered Phase 1 trials.

Researchers at the University of Gothenburg have identified a molecule that helps more mitochondria function properly. Mitochondrial diseases caused by POLG mutations vary in severity. In young ...

With just 48 hours to experiment before it would become unusable, a group of nearly 20 researchers focused intently on creating a brand-new molecule. Using a chemical glove box, a polycarbonate ...

Ask someone to name a favorite shape, and they’ll probably choose one of the usual suspects: triangle, circle, maybe a trapezoid. These run-of-the-mill forms take a back seat to more ...

Wang et al. pursued a fresh approach by instead attaching antigens to a molecule that guides them to a key organelle — the endoplasmic reticulum (ER). This subcellular compartment is where ...

Get Instant Summarized Text (Gist) A new AI method integrates large language models (LLMs) with graph-based models to enhance molecule creation, improving efficiency and explainability. This ...

Now, researchers at the University of Gothenburg have discovered a small molecule that restores function in a defective mitochondrial enzyme, offering a new therapeutic avenue for diseases caused by ...

Small-molecule drug investment has fallen 68%—and 74% for diseases mainly affecting Medicare patients—since the IRA was introduced “This decline in innovation means fewer options at a higher ...

A team of researchers from McMaster University has identified a new molecule – lariocidin – that can challenge some of the most drug-resistant bacteria on Earth. The discovery responds to a critical ...