Checkpoint kinase1 (CHK1), which is a key component of DNA ... The immunohistochemical staining was performed using Novocastra Novolink polymer detection kit system (Leica Microsystem, Newcastle ...

Remarkably, Chk1 deletion rapidly triggered spontaneous cell proliferation, γ-H2AX staining and apoptosis within the hair follicle, a principal site of origin for carcinogen-induced tumors.

Robert Abraham, Ph.D., former director of The Burnham Institute's Cancer Center and now vice president for oncology research at Wyeth Pharmaceuticals, together with his colleagues, found that the Chk1 ...

Furthermore these same conditions target Chk1 for eventual destruction. Ironically, stimulation of Chk1 triggers certain repair responses that fight cancer while the simultaneous degradation of ...

The anticancer effects of irinotecan chemotherapy on specific forms of triple-negative breast cancer (TNBC)can be significantly heightened by the addition of a targeted checkpoint kinase 1 (Chk1 ...

The poster “Tumors driven by oncogene amplified extrachromosomal DNA (ecDNA) demonstrate enhanced sensitivity to cell cycle checkpoint kinase 1 (CHK1) inhibition” is available for in-person ...

Small molecule drug discoverer Sentinel Oncology has made an agreement with Oncothyreon toward developing Sentinel’s Checkpoint Kinase 1 (Chk1) program under which Oncothyreon will fund ...

Hence ecDNA bearing cancer cells are hyper-reliant for survival on checkpoint kinase 1 (CHK1), cells’ master regulator of replication stress, and are hypersensitive to inactivation of CHK1.

Eli Lilly was also working on a CHK1 inhibitor, prexasertib, which it picked up from Array BioPharma. But it abandoned that development program last spring. Nevertheless, the Institute for Cancer ...