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There are a bunch of mini PCs available (or coming soon) with AMD Strix Halo processors featuring up to 16 Zen 5 CPU cores, ...
There's also an in-between build with the Ryzen AI Max+ 395 chip and 64GB of RAM for $1,599. If you just want the mini ITX board to put in a case of your choosing, that starts at $799.
This odd but surprisingly well-priced mini ITX motherboard from Minisforum packs an embedded AMD X3D ... you're probably hunting around for the best mini ITX motherboard to house the Ryzen X3D chip.