The San Francisco 49ers are set to visit Highmark Stadium this weekend for a critical Week 13 showdown against the Buffalo ...

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks ...

This will be a true test for the defense and depending on the outcome, the Steelers' Super Bowl odds are sure to move. Arizona Cardinals (+7,000 to +5,500) With a healthy Kyler Murray, the Arizona ...

They rest of the roster is littered with Pro Bowl players, and how a team played in September and October only matters in January if the team is sitting home. The 49ers were an NFC Super Bowl ...

But your reaction seems reasonable. Five years ago, the 49ers breezed through the NFC and had a 10-point lead in the Super Bowl. Losing that game was their first big heartbreak. The next season ...

and NFL writer Charles McDonald discuss whether the return of Christian McCaffrey is enough to get the 49ers back to the Super Bowl. Hear the full conversation on “Football 301” - and ...

The last time New Orleans hosted the big game was Super Bowl XLVII between the Baltimore Ravens and San Francisco 49ers on Feb. 3, 2013, and that Super Bowl week created an economic impact of $480 ...

The 49ers have played nine games. When will we see a team that looks worthy of Super Bowl contention? We didn’t see that level of play before the team’s bye week. And we didn’t see it upon ...

Deebo Samuel was mentioned as a possible candidate to be moved before Tuesday’s trade deadline, but the 49ers opted to keep the All-Pro wideout for another Super Bowl run. Samuel had five ...

Yes, with a .500 record entering the second half of the season, the 49ers are certainly not in a position to worry about style points following Sunday’s 23-20 win over the Buccaneers. But I’m ...