Additional efforts are needed to improve quality of life and mitigate suffering in people with sickle cell disease. The field ...

The concept of adjuvant therapy for cancer was developed at a time when systemic cancer treatment was limited to cytotoxic chemotherapy that could only be administered intermittently but rarely ...

When a pediatrician caring for patients with a rare genetic disease discovers incidentally that he carries his own rare high-risk mutation, he must learn from a patient’s parents how to shift his ...

A baby boy was transferred to a tertiary care hospital 5 days after birth. He had an intact manubrium but no corpus of the sternum, which had resulted in complete displacement of the heart outside ...

A 43-year-old woman with bipolar disorder and advanced HIV infection was admitted to this hospital because of depressed mood, suicidal ideation, cough, and a temperature of 39.5°C. A diagnosis was ...

Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; ...

New models integrating clinic-based care with community-based services for people with substance use disorder could reduce the time to stable remission and support recovery.

More than 95% of patients with idiopathic intracranial hypertension are women of childbearing age with obesity. 4 Men are seldom affected, for unknown reasons. Even among women with obesity the ...

A 22-year-old woman presented with a 3-month history of bumps on the right ventral surface of her tongue. On physical examination, the bumps were observed to be pink papillomatous lesions measuring 3 ...

The financial assistance policies of some U.S. hospitals now define medical necessity much more restrictively than it has conventionally been understood, as covering only services that are urgently ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 21).