The first wave of PARP inhibitors has improved outcomes in people with a variety of solid tumors. However, Idience has identified opportunities to improve the efficacy of existing drugs and ...
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Saruparib demonstrates early efficacy in breast cancers with DNA repair defects in Phase I/II trialPoly-ADP ribose polymerase (PARP) inhibition previously was shown ... The most common adverse events were anemia, neutropenia, thrombocytopenia, fatigue and asthenia. According to Yap, the safety ...
Results from the PAOLA-1 study showed that the PARP inhibitor drug significantly increased the time women lived without disease progression when added to the standard-of-care, Genentech’s ...
News Medical on MSN3d
Study sheds light on how major cancer gene influences the success of PARP inhibitorsA study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP inhibitors.
AbbVie’s hopes of getting a so-called PARP inhibitor cancer drug to market are fading after its veliparib failed in two late-stage studies. AstraZeneca’s Lynparza (olaparib) is becoming well ...
LAE120 is a novel, allosteric and highly potent USP1 inhibitor, displaying monotherapy potency and combination activity with PARP inhibitor in HRD (homologous recombination deficiency) cancers.
Pharmaceutical Technology on MSN3mon
Eisbach Bio positions HRD-targeting therapy to supplant PARP inhibitorsA $4.75m grant will support the development of EIS-12656, which is being studied alone and in combination with PARP inhibitors.
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