The Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to BXCL501 (dexmedetomidine; BioXcel Therapeutics) for the acute treatment of agitation associated with dementia.

BioXcel Therapeutics Announces Positive Topline Results from Post-Marketing Requirement Study Evaluating PRN Treatment of IGALMI™ (dexmedetomidine) Sublingual Film for Agitation Associated with ...

The researchers found that dexmedetomidine reduced the etomidate-induced sustained increase in α5 γ-aminobutyric acid type A receptor cell-surface expression (etomidate: 146.4 ± 51.6% ...

A constant dexmedetomidine dose paired with an increasing propofol dose lowered the risk for mortality in ICU patients aged 65 years or younger, according to results published in American Journal ...

Dexmedetomidine administration early in the postpartum period was associated with significantly lower positive postpartum depression incidence compared with placebo, researchers reported in JAMA ...

Cite this: A Cost-Minimization Analysis of Dexmedetomidine Compared With Midazolam For Long-Term Sedation In The Intensive Care Unit. F1000: "Changes Clinical Practice" - Medscape - Apr 05, 2010.

For women with prenatal depression undergoing cesarean delivery, dexmedetomidine reduces the incidence of positive postpartum depression (PPD) screening, according to a study published online Jan ...

For the study, researchers randomly assigned patients to receive dexmedetomidine, a sedative, or a saline placebo infusion during surgery and for two hours while in recovery. They assessed ...

In the 125patients (82 LD and 43 HD) who received dexmedetomidine for at least 8 hours, use of any concomitant CIV sedative after 8 hours was significantly higher in the HD group(53.5% vs 26.8%; p ...

A study published in the June 2011 issue of the Annals of Pharmacotherapy indicates that increasing doses of the drug dexmedetomidine may not enhance sedation in critically ill patients, according ...

To investigate the effect of systemic administration dexmedetomidine, a selective alpha 2 adrenergic receptor (α2AR) agonist, on thermal hyperalgesia and spinal glial activation evoked by ...