More information: Russell W. Cochrane et al, High-affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells, Molecular Therapy - Methods & Clinical ...

T cell activation requires a T cell receptor (TCR) to recognize its cognate ... transmits the activation signal to intracellular signalling molecules to initiate a signalling cascade in the ...

Statistics show hundreds of thousands of systemic bacterial and fungal infections are diagnosed each year in the United ...

Signal transduction by cell adhesion receptors and the cytoskeleton ... Parsons, J. T. et al. Focal adhesion kinase: Targeting adhesion signaling pathways for therapeutic intervention.

Early clinical results suggest the firm's antibodies targeting the Vβ T-cell receptor could induce strong and durable responses in cancer patients.

In atopic dermatitis, psoriasis and other dermatologic diseases, T cells lose tolerance to self-antigens, triggering the autoimmune response that leads to abnormal skin cell proliferation and ...

B-cell acute lymphoblastic leukemia (B-ALL) is a life-threatening and highly aggressive form of blood cancer. It is the most ...

Discover how the ALA-CART platform enhances CAR T cell efficacy against antigen-low leukemias. With improved LAT activation, ...

Treatment of B-cell Acute Lymphoblastic Leukaemia has improved thanks to CAR-T therapies, but relapse is still very common.