PHILADELPHIA—Initiating treatment of type 2 diabetes with sulfonylurea drugs is associated with an increased risk of renal function decline, end-stage renal disease (ESRD), or death compared with ...
A comparative effectiveness research study compared MACE rates among initiators of sulfonylureas versus DPP4 inhibitors for T2D. Glipizide in particular showed a significant link to cardiovascular ...
Epac2, a guanine nucleotide exchange factor for the small guanosine triphosphatase Rap1, is activated by adenosine 3′,5′-monophosphate. Fluorescence resonance energy transfer and binding experiments ...
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