Medscape7d
The Glucagonostatic and Insulinotropic Effects of Glucagon-like Peptide 1 Contribute Equally to its Glucose-lowering Action
On day 1, GLP-1 was infused to stimulate endogenous insulin release and suppress endogenous glucagon. On days 2–5, pancreatic endocrine clamps were performed using somatostatin infusions of ...
Medscape28d
Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
Somatostatin (SST) is secreted by islet δ-cells and by extraislet neuroendocrine cells. SST receptors have been identified on α- and β-cells, and exogenous SST inhibits insulin and glucagon ...
News-Medical.Net on MSN5d
Flavonoids help regulate gut hormones and show promise in managing type 2 diabetes
Flavonoids show promise in treating type 2 diabetes mellitus by targeting the enteroendocrine system and regulating key gut ...
The Scientist4mon
A Sea Snail Toxin Could Inspire New Diabetes Drugs
One hormone that could serve this function is somatostatin, which acts as a brake to prevent blood sugar from rising to normal levels. Blood glucose levels are mainly regulated by the opposing actions ...
Transplanting insulin-making cells to treat Type 1 diabetes is challenging − but stem cells offer a potential improvement
They are present in clusters of cells that produce other hormones involved in metabolism, such as glucagon, which increases ...
Nature4y
G-Protein-Coupled Receptors, Pancreatic Islets, and Diabetes
beta cells secrete insulin, and alpha cells secrete glucagon. Scientists have identified three additional cell types in islets, including cells that secrete the hormones somatostatin, ghrelin ...