Metformin-associated lactic acidosis was associated with elevated blood lactate levels (>5 mmol/L), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ...

In severe cases, metformin may cause lactic acidosis. Lactic acidosis is a dangerous complication that causes a buildup of lactic acid in the body. This can lead to diabetic coma and might even be ...

Glyburide, metformin HCl; 2.5mg/500mg ... See Contraindications. Increased risk of lactic acidosis with topiramate, other carbonic anhydrase inhibitors (eg, zonisamide, acetazolamide ...

Indeed, phenformin, an antidiabetic drug that belongs to the same class as metformin, was withdrawn from the market in 1977 because of the high incidence of lactic acidosis associated with its use.

A less frequent but severe side effect of metformin is lactic acidosis, where lactic acid builds up in the blood because the muscles can’t break down glucose. It’s also worth noting that ...

Objective Many societies recommend using estimated glomerular filtration rate (eGFR) rather than serum creatinine (sCr) to determine metformin eligibility. We examined the potential impact of ...