The replication fork is more than just a means for DNA duplication. It is connected to a checkpoint system that keeps the genome intact and prevents cancer. Aa Aa Aa Eukaryotic genomes are ...

This forms two replication forks that move along the ... Also, whereas bacterial chromosomes are circular, eukaryotic chromosomes are linear. During circular DNA replication, the excised primer ...

Arrested replication forks are prone to collapse, posing serious threats to genomic integrity, suggesting that DNA replication problems are critical ... that are highly conserved amongst most ...

We employ fully reconstituted yeast and human DNA replication systems to investigate the structure and biochemical mechanism of the eukaryotic replication machinery ... the normal progression of ...

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

Chromosome Cohesion: In eukaryotes, replicated chromosomes are held ... in which replicated DNA is linked together as it exits the replication fork, remaining stably attached for 10-20 minutes before ...

Chen “P53 Inhibits Strand Exchange and Replication Fork Regression Promoted by Human Rad51,” J. Mol. Biol., (2004) 336, 639 – 654. R. Deaton, J-W Kim and J. Chen “Design and Test of ...