Cell-matrix adhesion is formed through the utilization of cell adhesion molecules that bind to the cell surface of the ECM. Anchor proteins are also used to mediate linkages, or are employed in ...

Adhesion-contact-like structures have been observed in vivo in smooth muscle cell plaques and myotendinous junctions 124 and, recently, in embryonic three-dimensional ECM 125, thereby validating ...

Cancer cells also rely on cell–matrix interactions to spread around the body. Crystal-gazing. How do cells grab on, let go, and otherwise interact with the ECM? The inventors of the new techniques ...

Cell adhesion phenotypes were also much clearer on the 3-D constructs compared to attachments on 2-D. Typically, cells attach to material surfaces or the extracellular matrix (ECM) via anchorage ...

A critical step in cell migration is the interaction between the cell and the extracellular matrix (ECM). The cell connects to the ECM via the actin cytoskeleton. This connection is mediated by ...

"The study highlights the close interaction between lysosomal exocytosis and focal adhesions, underscoring their critical ...

For our cells to assemble into tissues and whole organs, the extracellular ma-trix (ECM) as well as the integrins are required. The ECM forms a kind of extra-cellular protein meshwork, the ...

Movement of cells taking place during embryonic development, in patho-physiological conditions or in diseased states (e.g., as a primary mode to generate ...

Using genetics and protein visualization techniques, the team found that Dumpy, a fibrous ECM protein, mediates the adhesion of cell sheets to their surroundings. Additionally, ...

At cell-cell junctions, adhesion receptors at the cell surface are linked via adaptor proteins to the cytoskeleton, a structural scaffold inside the cell composed of filamentous proteins like actin.

As a renowned researcher, Murphy-Ullrich had a hand in several significant discoveries, including the identification of a cellular de-adhesive role for matricellular extracellular matrix (ECM) ...