PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

This resistance can occur due to mutations in the estrogen receptor gene (ESR1) or through the activation of alternative pathways that allow the cancer to continue growing even when hormone ...

Pfizer and Arvinas’ estrogen receptor (ER) degrader has failed a key part of its first phase 3 test, although the companies have pointed to success in a subpopulation to suggest the therapy ...