The 49ers look to turn around their season with a win in Buffalo against the Bills, who are chasing the top seed in the AFC.

At +7500 as of Nov. 30, the San Francisco 49ers aren't among the favorites to win the Super Bowl this season. The 49ers picked up a 38-10 loss to the Green Bay Packers in their last game.

San Francisco 49ers three-time Super Bowl champion has suddenly passed away at 80, the team announced on Thursday.

The banged-up 49ers fell 38-10 to Green Bay and their Super Bowl futures plummeted to +8000 from +2200. The Niners weren't the only team whose odds moved down the board. The Texans also saw their ...

One of the explanations commonly tossed out for the team’s issues this season is the dreaded ‘Super Bowl hangover’ teams experience after falling short at the league’s highest stage. Head coach Kyle ...

Sunday's loss to the Seahawks was another offensive slog for a team that isn't looking very Super Bowl-hopeful so far this ...

But your reaction seems reasonable. Five years ago, the 49ers breezed through the NFC and had a 10-point lead in the Super Bowl. Losing that game was their first big heartbreak. The next season ...

The San Francisco 49ers are hungover from their Super Bowl loss to the Kansas City Chiefs nine months ago. This is always a question posed to the losing team of a championship game going into the ...

Super Bowl 47, which was played on Feb. 3, 2012, in New Orleans, featured Jim Harbaugh's 49ers against John Harbaugh's Ravens. As the Harbaugh brothers get set to match up against each other once ...

They rest of the roster is littered with Pro Bowl players, and how a team played in September and October only matters in January if the team is sitting home. The 49ers were an NFC Super Bowl ...