Multi-ubiquitinated proteins are recognized by the 26S proteasome and degraded. This irreversible process has evolved into a central regulator of many different signaling pathways. The book is ...

The ubiquitinated proteins are subsequently recognized and degraded by a complex multicatalytic protease called the 26S proteasome. The component of the APC responsible for mediating this reaction ...

Much like humans generate mountains of garbage, our cells are constantly discarding proteins that are damaged or no longer ...