Five Chiefs players were injured in Kansas City's loss to the Seattle Seahawks in Week 2 of the 2025 NFL preseason.

The Chiefs fell to the Seahawks 33-16 in the second preseason game on a rainy night in Seattle. Andy Reid followed through on his suggestion earlier in the week that key players like Patrick Mahomes and Chris Jones wouldn't play. The offense, led by Gardner Minshew, moved the ball and punched in a touchdown on one of two possessions.

Sam Darnold looked the part of a franchise quarterback in his first appearance at Lumen Field as the Seattle Seahawks beat the Kansas City Chiefs 33-16 in a preseason game.